[CH3:1][N:2]([C:6]1[CH:7]=[CH:8][C:9]([C:20]([F:23])([F:22])[F:21])=[C:10]2[C:14]=1[NH:13][C:12]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:11]2)[CH2:3][CH2:4][OH:5].C(N(CC)CC)C.O1CCCC1.[CH3:36][S:37](Cl)(=[O:39])=[O:38]>O>[CH3:1][N:2]([C:6]1[CH:7]=[CH:8][C:9]([C:20]([F:23])([F:22])[F:21])=[C:10]2[C:14]=1[NH:13][C:12]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:11]2)[CH2:3][CH2:4][O:5][S:37]([CH3:36])(=[O:39])=[O:38]A mixture of ethyl 7-[N-methyl-N-(2-hydroxyethyl)amino]-4-trifluoromethyl-1H-indole-2-carboxylate (0.37 g, 1.12 mmol)., triethylamine (0.25 g, 2.46 mmol) and tetrahydrofuran (20 ml) was cooled to −19° C., after which methanesulfonyl chloride (0.14 g, 1.23 mmol) was added dropwise with stirring. The reaction mixture was stirred at −18° C. to −13° C. for 1 hour, poured into cold water, and then extracted three times with ethyl acetate. The extract solution was washed with a 5% aqueous sodium hydrogencarbonate solution and a 5% aqueous sodium chloride solution and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to obtain an oil of ethyl 7-[N-methyl-N-(2-methanesulfonyloxyethyl)amino]-4-trifluoromethyl-1H-indole-2-carboxylate.
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