Mandelic Acid → Sotalol

HRID 651495

Reaction equation

HRID 651495 reaction equation
[CH3:1][CH:2]([NH:4][CH2:5][C@@H:6]([OH:18])[C:7]1[CH:12]=[CH:11][C:10]([NH:13][S:14]([CH3:17])(=[O:16])=[O:15])=[CH:9][CH:8]=1)[CH3:3].Cl.C(O)(=O)C(C1C=CC=CC=1)O>>[CH3:3][CH:2]([NH:4][CH2:5][CH:6]([OH:18])[C:7]1[CH:8]=[CH:9][C:10]([NH:13][S:14]([CH3:17])(=[O:16])=[O:15])=[CH:11][CH:12]=1)[CH3:1]

Participants

3

Reactant 2

HCID 1292Mandelic AcidHCID 165245Dexsotalol Hydrochloride

Product 1

HCID 5253Sotalol

Procedure

In addition, using chemical method as described by Le Garrec (1987), enriched d-sotalol hydrochloride and l-sotalol hydrochloride were prepared using mandelic acid and subjected to conversion to the base form, chiral separation and reconversion to hydrochloride salt was carried out. The details of these procedures are given below:

Workup

  1. customwere prepared
  2. customsubjected to conversion to the base form, chiral separation and reconversion to hydrochloride salt

Sources & evidence

ORD record
ord-b1da450602074d29b7a1aa7f0ca08711
Source dataset
uspto-grants-2001_08
Patent number
US06281246B1

Linked notes

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