Hydrochloric Acid → 1-(2-Bromoethyl)-4-(methoxymethyl)benzene
Reaction equation
[Br:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][OH:11])=[CH:6][CH:5]=1.[C:12]1(S(OC)(=O)=O)C=CC=CC=1.C([O-])([O-])=O.[K+].[K+].Cl>CO>[CH3:12][O:11][CH2:10][C:7]1[CH:8]=[CH:9][C:4]([CH2:3][CH2:2][Br:1])=[CH:5][CH:6]=1Participants
6
Procedure
The 1-(2-bromoethyl)-4-hydroxymethylbenzene (0.5 g) is then added to a solution of 0.44 g methyl benzene-sulfonate and 0.32 g K2CO3 in 10 mL of methanol and allowed to react for 4 h. The solution is neutralized with methanolic HCl and extracted with ether. The ether extract is dried over Na2SO4, filtered, and the solvent removed under vacuum to yield 1-(methoxymethyl)-4-(2-bromoethyl)benzene (13).
Workup
- customto react for 4 h
- extractionextracted with ether
- extractionThe ether extract
- dry with materialis dried over Na2SO4
- filtrationfiltered
- customthe solvent removed under vacuum
Sources & evidence
- ORD record
- ord-f3d7f2735bef413f9bd37c0c5fba0c3a
- Source dataset
- uspto-grants-1987_06
- Patent number
- US04672071
Reaction notes
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