Dimethylformamide dimethyl acetal → 7H-Naphtho(1,2,3-ij)(2,7)naphthyridin-7-one
Reaction equation
COC(OC)[N:4]([CH3:6])[CH3:5].[CH3:9][C:10]1[CH:11]=[CH:12][N:13]=C2[C:24](=[O:25])[C:23]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[C:16](=O)[C:15]=12>CN(C)C=O>[CH:20]1[CH:21]=[CH:22][C:23]2[C:24](=[O:25])[C:5]3[C:15]4[C:10]([CH:9]=[CH:6][N:4]=3)=[CH:11][CH:12]=[N:13][C:16]=4[C:18]=2[CH:19]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Dimethylformamide dimethyl acetal (1.50 mL, 11.34 mmol, Aldrich) was added to a solution of cleistopholine, (1.95 g, 8.73 mmol) in dimethylformamide (5 mL). The mixture was then heated for 30 min by submerging
Workup
- temperatureThe mixture was then heated for 30 min
Sources & evidence
- ORD record
- ord-77d63ea9d6e74c1ebb14483c828a2966
- Source dataset
- uspto-grants-1992_07
- Patent number
- US05128344
Reaction notes
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