Dimethylformamide → 3-Cyano-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]-4-[4-(3-methoxyprop-1-ynyl)benzofuran-7-ylamino]quinoline

HRID 669342

Reaction equation

HRID 669342 reaction equation
[CH3:11][O:12][CH2:13][C:14]#[C:15][c:16]1[cH:17][cH:18][c:19]([NH2:25])[c:20]2[c:21]1[cH:22][cH:23][o:24]2.[CH3:1][SiH:2]([CH3:3])[N:4]([CH3:5])[Si:6]([CH3:7])([CH3:8])[CH3:9].[Cl:26][c:27]1[c:28]([C:50]#[N:51])[cH:29][n:30][c:31]2[cH:32][c:33]([O:39][CH2:40][CH2:41][CH2:42][N:43]3[CH2:44][CH2:45][N:46]([CH3:49])[CH2:47][CH2:48]3)[c:34]([O:37][CH3:38])[cH:35][c:36]12.[Na:10].[O:52]=[CH:53][N:54]([CH3:55])[CH3:56]>>[CH3:11][O:12][CH2:13][C:14]#[C:15][c:16]1[cH:17][cH:18][c:19]([NH:25][c:27]2[c:28]([C:50]#[N:51])[cH:29][n:30][c:31]3[cH:32][c:33]([O:39][CH2:40][CH2:41][CH2:42][N:43]4[CH2:44][CH2:45][N:46]([CH3:49])[CH2:47][CH2:48]4)[c:34]([O:37][CH3:38])[cH:35][c:36]23)[c:20]2[c:21]1[cH:22][cH:23][o:24]2

Participants

6

Reactant 5

HCID 6228DimethylformamideHCID 589711N-dimethylsilyl-N-trimethylsilylmethanamineHCID 5360545SodiumHCID 117491774-Chloro-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinoline-3-carbonitrileHCID 21082722[4-(3-Methoxyprop-1-ynyl)benzofuran-7-yl]amine

Product 1

HCID 98719693-Cyano-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]-4-[4-(3-methoxyprop-1-ynyl)benzofuran-7-ylamino]quinoline

Sources & evidence

ORD record
ord-dbdad584c13843f4b9eb636f2982fa21
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Linked notes

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