Acetonitrile → Tert-butyl (6-(3-hydroxy-4-methylpent-1-ynyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methylcarbamate

HRID 676724

Reaction equation

HRID 676724 reaction equation
[CH3:20][CH:21]([CH:22]([C:23]#[CH:24])[OH:25])[CH3:26].[CH3:27][CH2:28][N:29]([CH2:30][CH3:31])[CH2:32][CH3:33].[CH3:34][C:35]#[N:36].[Cl:1][c:2]1[cH:3][cH:4][c:5]2[n:6]([n:7]1)[c:8]([CH2:11][NH:12][C:13]([O:14][C:15]([CH3:16])([CH3:17])[CH3:18])=[O:19])[n:9][n:10]2.[Cl:37][CH2:38][Cl:39].[Cu:40][I:41]>>[c:2]1([C:24]#[C:23][CH:22]([CH:21]([CH3:20])[CH3:26])[OH:25])[cH:3][cH:4][c:5]2[n:6]([n:7]1)[c:8]([CH2:11][NH:12][C:13]([O:14][C:15]([CH3:16])([CH3:17])[CH3:18])=[O:19])[n:9][n:10]2

Participants

7

Reactant 6

HCID 6342AcetonitrileHCID 6344DichloromethaneHCID 8471TriethylamineHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 982794-Methylpentyn-3-olHCID 57691389tert-Butyl ((6-chloro-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)carbamate

Product 1

HCID 57691276Tert-butyl (6-(3-hydroxy-4-methylpent-1-ynyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methylcarbamate

Sources & evidence

ORD record
ord-9950090cd8604c70bb308c960e22dbcd
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Linked notes

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