Dimethylformamide → Ethyl 4-[[2-(2-cyanopyrrolidin-1-yl)-2-oxoethyl]amino]bicyclo[2.2.2]octane-1-carboxylate

HRID 679709

Reaction equation

HRID 679709 reaction equation
[Br:24][CH2:25][C:26](=[O:27])[N:28]1[CH:29]([C:33]#[N:34])[CH2:30][CH2:31][CH2:32]1.[CH3:35][N:36]([CH3:37])[CH:38]=[O:39].[CH:15]([N:16]([CH:17]([CH3:18])[CH3:19])[CH2:20][CH3:21])([CH3:22])[CH3:23].[NH2:1][C:2]12[CH2:3][CH2:4][C:5]([C:10](=[O:11])[O:12][CH2:13][CH3:14])([CH2:6][CH2:7]1)[CH2:8][CH2:9]2>>[NH:1]([C:2]12[CH2:3][CH2:4][C:5]([C:10](=[O:11])[O:12][CH2:13][CH3:14])([CH2:6][CH2:7]1)[CH2:8][CH2:9]2)[CH2:25][C:26](=[O:27])[N:28]1[CH:29]([C:33]#[N:34])[CH2:30][CH2:31][CH2:32]1

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 81531DiisopropylethylamineHCID 178609191-(2-Bromoacetyl)pyrrolidine-2-carbonitrileHCID 23149693Ethyl 4-aminobicyclo[2.2.2]octane-1-carboxylate

Product 1

HCID 23149687Ethyl 4-[[2-(2-cyanopyrrolidin-1-yl)-2-oxoethyl]amino]bicyclo[2.2.2]octane-1-carboxylate

Sources & evidence

ORD record
ord-4b8183ae10a644acafdddb8c76c9a3f0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Linked notes

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