Tetrahydrofuran → N-(2-cyanocyclohexyl)-3,5-difluoro-4-(2-propynyloxy)benzamide

HRID 691056

Reaction equation

HRID 691056 reaction equation
[CH3:1][Si:2]([CH3:3])([CH3:4])[C:5]#[N:6].[CH3:29][CH2:30][CH2:31][CH2:32][N+:33]([CH2:34][CH2:35][CH2:36][CH3:37])([CH2:38][CH2:39][CH2:40][CH3:41])[CH2:42][CH2:43][CH2:44][CH3:45].[F-:28].[F:7][c:8]1[cH:9][c:10]([C:11](=[O:12])[N:13]2[CH:14]3[CH2:15][CH2:16][CH2:17][CH2:18][CH:19]23)[cH:20][c:21]([F:27])[c:22]1[O:23][CH2:24][C:25]#[CH:26].[O:46]1[CH2:47][CH2:48][CH2:49][CH2:50]1>>[C:5](#[N:6])[CH:14]1[CH2:15][CH2:16][CH2:17][CH2:18][CH:19]1[NH:13][C:11]([c:10]1[cH:9][c:8]([F:7])[c:22]([O:23][CH2:24][C:25]#[CH:26])[c:21]([F:27])[cH:20]1)=[O:12]

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 16028TetrabutylammoniumHCID 28179Fluoride IonHCID 82115Trimethylsilyl cyanideHCID 577011787-[3,5-Difluoro-4-(2-propynyloxy)benzoyl]-7-azabicyclo[4.1.0]heptane

Product 1

HCID 57701183N-(2-cyanocyclohexyl)-3,5-difluoro-4-(2-propynyloxy)benzamide

Sources & evidence

ORD record
ord-f639b9d003d24ee2bfab83e8606ce6bd
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Linked notes

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