p-Toluenesulfonic acid → 2-{[2'-(bromomethyl)-4-fluoro-5-isopropyl-2-methoxy-4'-(trifluoromethyl)biphenyl-3-yl]oxy}tetrahydro-2H-pyran
Reaction equation
[Br:18][CH2:19][c:20]1[c:21](-[c:30]2[c:31]([O:41][CH3:42])[c:32]([OH:40])[c:33]([F:39])[c:34]([CH:36]([CH3:37])[CH3:38])[cH:35]2)[cH:22][cH:23][c:24]([C:26]([F:27])([F:28])[F:29])[cH:25]1.[CH2:1]1[CH2:2][O:3][CH:4]=[CH:5][CH2:6]1.[Cl:43][CH2:44][Cl:45].[c:7]1([CH3:8])[cH:9][cH:10][c:11]([S:12]([OH:13])(=[O:14])=[O:15])[cH:16][cH:17]1>>[CH2:1]1[CH2:2][O:3][CH:4]([O:40][c:32]2[c:31]([O:41][CH3:42])[c:30](-[c:21]3[c:20]([CH2:19][Br:18])[cH:25][c:24]([C:26]([F:27])([F:28])[F:29])[cH:23][cH:22]3)[cH:35][c:34]([CH:36]([CH3:37])[CH3:38])[c:33]2[F:39])[CH2:5][CH2:6]1Participants
5
