Dimethylformamide → 2-Bromo-2-(4-fluorophenyl)acetamide

Reaction equation

[Br:1][CH:2]([C:3](=[O:4])[OH:5])[c:6]1[cH:7][cH:8][c:9]([F:12])[cH:10][cH:11]1.[Cl:18][C:19]([C:20]([Cl:21])=[O:22])=[O:23].[Cl:24][CH2:25][Cl:26].[O:13]=[CH:14][N:15]([CH3:16])[CH3:17]>>[Br:1][CH:2]([C:3](=[O:4])[NH2:15])[c:6]1[cH:7][cH:8][c:9]([F:12])[cH:10][cH:11]1

Participants

Reactant 4

HCID 6228Dimethylformamide

HCID 6344Dichloromethane

HCID 65578Oxalyl chloride

HCID 16217752Bromo(4-fluorophenyl)acetic acid

Product 1

HCID 109663582-Bromo-2-(4-fluorophenyl)acetamide

Sources & evidence

ORD record: ord-48dc829f38c64c04998bb8d03b54c1f3
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (3/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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