2-Amino-4-chloro-6-methylpyrimidine → HCID 58395746, compound

HRID 69947

Reaction equation

HRID 69947 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([NH2:9])[N:3]=1.[O:10](C(OC(C)(C)C)=O)[C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=O>CN(C1C=CN=CC=1)C>[Cl:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([N:9]([C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:10])[C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:10])[N:3]=1

Participants

4

Reactant 2

HCID 218102-Amino-4-chloro-6-methylpyrimidineHCID 90495Di-tert-butyl dicarbonate

Product 1

HCID 58395746HCID 58395746, compound

Reagents, catalysts & solvents 1

HCID 142844-(Dimethylamino)pyridineCatalyst

Procedure

Method 24 was followed using 4-chloro-6-methylpyrimidin-2-amine (1.0 equiv.), BOC2O (2.0 equiv.), and DMAP (cat.) to afford 4-chloro-N,N-di-BOC-6-methylpyrimidin-2-amine in 71%. LCMS (m/z): 344.2 (MH+); LC Rt=4.3 min.

Sources & evidence

ORD record
ord-4e69f75b88c7414ba88fdc4f50c19346
Source dataset
uspto-grants-2014_09
Patent number
US08822497B2

Linked notes

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