Nitrate → HCID 59627748, compound

Reaction equation

C[O:2][C:3]([C:5]1[CH:6]=[C:7]([C:12]2[CH:17]=[CH:16][C:15]([CH3:18])=[CH:14][CH:13]=2)[CH:8]=[C:9](N)[CH:10]=1)=[O:4].C(I)[I:20].[N+]([O-])([O-])=O>>[I:20][C:9]1[CH:10]=[C:5]([C:3]([OH:2])=[O:4])[CH:6]=[C:7]([C:12]2[CH:17]=[CH:16][C:15]([CH3:18])=[CH:14][CH:13]=2)[CH:8]=1

Participants

Reactant 3

HCID 943Nitrate

HCID 6346Diiodomethane

HCID 57850917Methyl 5-amino-4'-methylbiphenyl-3-carboxylate

Product 1

HCID 59627748HCID 59627748, compound

Procedure

5-Amino-4′-methyl-biphenyl-3-carboxylic acid methyl ester was treated with methylene iodide and isoamy nitrate using the procedure of step 5 of preparation 5, to afford 5-iodo-4′-methyl-biphenyl-3-carboxylic acid, MS (M+H)=353.

Workup

customthe procedure of step 5 of preparation 5

Sources & evidence

ORD record: ord-19673ba8861d47f3b644338ff50df5b4
Source dataset: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09173861B2

Reaction notes

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