Potassium Carbonate → HCID 178513240, compound
Reaction equation
[C:1]([C:3]1[CH:11]=[CH:10][C:6]2[N:7]=[CH:8][NH:9][C:5]=2[CH:4]=1)#[N:2].C([O-])([O-])=O.[K+].[K+].Cl.[NH2:19][OH:20]>CCO.CCOCC>[OH:20][NH:19][C:1]([C:3]1[CH:11]=[CH:10][C:6]2[NH:7][CH:8]=[N:9][C:5]=2[CH:4]=1)=[NH:2]Participants
6
Reactant 3
Product 1
Reagents, catalysts & solvents 2
Procedure
A solution of 5-cyanobenzimidazole (1.43 g; 10 mmol; 1 eq.) in EtOH (30 ml) was treated with K2CO3 (2.76 g; 20 mmol; 2 eq.) and hydroxylaminehydrochloride (765 mg; 11 mmol; 1.1 eq.) and heated to reflux over night. After cooling to room temperature, the mixture was diluted with Et2O. The resulting solid was collected by filtration, washed with Et2O and water and used without further purification. Yield: 1.28 g (72.7%); MS m/z: 177.3 [M+H]+
Workup
- temperatureheated
- temperatureto reflux over night
- filtrationThe resulting solid was collected by filtration
- washwashed with Et2O and water
- customused without further purification
Sources & evidence
- ORD record
- ord-bf3b1cccb195437ea40fa5c1bf4a264e
- Source dataset
- uspto-grants-2015_11
- Patent number
- US09181233B2
Reaction notes
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