Carbon Dioxide → Trichloropyrimidine-5-carboxylic acid

Temperature

-78 °C

To a solution of diisopropylamine (23.42 mL, 164 mmol) in THF (200 mL) was slowly added butyllithium (100 mL, 160 mmol) at −78° C. The mixture was stirred at −78° C. for 15 min. To this mixture was slowly added a solution of 2,4,6-trichloropyrimidine (20.06 g, 109 mmol) in THF (50 mL) at −78° C. The mixture was stirred for 1 h. Dry ice was added and the mixture was stirred at RT for 1 h. To the mixture was added 1N HCl, which was subsequently extracted with EtOAc. The organic layers were basified with aqueous NaHCO3, and washed with EtOAc. The aqueous layer was then acidified with 1N HCl, and extracted with EtOAc. The organic layers were washed with 1N HCl, water, and brine, were dried over anhydrous MgSO4, and then filtered. The filtrate was concentrated under reduced pressure. The residue was washed with hexane to give the desired product as a pale brown solid (12.28 g, 49%). 1H NMR (500 MHz, CDCl3) δ ppm 7.65 (br s, 1H).

1. customat −78° C
2. stirringThe mixture was stirred for 1 h
3. stirringthe mixture was stirred at RT for 1 h
4. extractionwas subsequently extracted with EtOAc
5. washwashed with EtOAc
6. extractionextracted with EtOAc
7. washThe organic layers were washed with 1N HCl, water, and brine
8. dry with materialwere dried over anhydrous MgSO4
9. filtrationfiltered
10. concentrationThe filtrate was concentrated under reduced pressure
11. washThe residue was washed with hexane

ORD record

ord-9f0b273e740b406795a903b71d563922

Source dataset

uspto-grants-2015_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09181255B2