Methanol → 1-ethyloctahydro-1H-pyrrolo[3,4-b]pyridine
Reaction equation
C([N:8]1[CH2:16][CH:15]2[CH:10]([N:11]([CH2:17][CH3:18])[CH2:12][CH2:13][CH2:14]2)[CH2:9]1)C1C=CC=CC=1.CO>[OH-].[OH-].[Pd+2].CCOC(C)=O>[CH2:17]([N:11]1[CH2:12][CH2:13][CH2:14][CH:15]2[CH2:16][NH:8][CH2:9][CH:10]12)[CH3:18]Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
To a solution of 6-benzyl-1-ethyloctahydro-1H-pyrrolo[3,4-b]pyridine (2.58 g) in the mixture solvent of MeOH and EtOAc was added a catalytic amount of 20% Pd(OH)2/C. The mixture was stirred for 2 h at room temperature under H2 and filtered. The filtrate was concentrated in vacuo and the residue was used for the next step without further purification. The compound was characterized by the following spectroscopic data: MS (ESI, pos. ion) m/z: 155.2 (M+1).
Workup
- filtrationfiltered
- concentrationThe filtrate was concentrated in vacuo
- customthe residue was used for the next step without further purification
Sources & evidence
- ORD record
- ord-e6a92d2d6e3c460a9651db6509c8d81e
- Source dataset
- uspto-grants-2015_11
- Patent number
- US09181277B2
Reaction notes
Loading…