HomeMCPWorkbenchSkills
HomeWorkbenchNotificationsMe
llms.txt · MCP GuidePrivacy Policy · Terms of Service · Supportv1.8.0
  1. Home
  2. /Reaction

Hydrochloric Acid → 5-(4-Methoxyphenyl)-2-(thiophen-2-yl)oxazole-4-carboxylic acid

HRID 714959
Notes
Print preview

Reaction equation

HRID 714959 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[O:13][C:12]([C:14]3[S:15][CH:16]=[CH:17][CH:18]=3)=[N:11][C:10]=2[C:19]([O:21]CC)=[O:20])=[CH:5][CH:4]=1.[OH-].[Li+].Cl>CO.C(Cl)Cl>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[O:13][C:12]([C:14]3[S:15][CH:16]=[CH:17][CH:18]=3)=[N:11][C:10]=2[C:19]([OH:21])=[O:20])=[CH:5][CH:4]=1
ParticipantsConditionsProcedureWorkupSources & evidenceReaction notes

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 68518280Ethyl 5-(4-methoxyphenyl)-2-(thiophen-2-yl)oxazole-4-carboxylate

Product 1

HCID 292814635-(4-Methoxyphenyl)-2-(thiophen-2-yl)oxazole-4-carboxylic acid

Reagents, catalysts & solvents 2

HCID 887MethanolSolvent
HCID 6344
Dichloromethane
Solvent

Conditions

Temperature
50 °C

Procedure

To a solution of ethyl 5-(4-methoxyphenyl)-2-(thiophen-2-yl)oxazole-4-carboxylate in MeOH (2 mL) and DCM (0.5 mL) was added 1M aqueous lithium hydroxide solution (2 mL, 2 mmol). The reaction mixture was stirred at 50° C. overnight and then 2M aqueous HCl (0.125 mL) was added and the solvent removed in vacuo to afford 5-(4-methoxyphenyl)-2-(thiophen-2-yl)oxazole-4-carboxylic acid which was used without further purification.

Workup

  1. customthe solvent removed in vacuo

Sources & evidence

ORD record
ord-a49e6059fff34e4783bb69925901d559
Source dataset
uspto-grants-2015_11
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US09187465B2

Reaction notes

Loading…

On this pageParticipantsConditionsProcedureWorkupSources & evidenceReaction notes