Acetic Acid → N-cyclohexyl-2-nitro-4-(piperidin-1-ylmethyl)aniline

Temperature

60 °C

To a solution of 4-cyclohexylamino-3-nitrobenzaldehyde (10.3 g, 41.3 mmol) in dichloroethane (50 mL) was added piperidine (4.10 g, 48.2 mmol) followed by acetic acid (0.20 mL, cat.). The reaction mixture was heated to 60° C. and stirred for 1 hr, then cooled to room temperature and sodium triacetoxyborohydride (10.5 g, 49.5 mmol) was added in a single portion. After stirring for 18 hr at room temperature, the reaction was quenched by the addition of sodium bicarbonate (sat., aq., 100 mL), and the mixture was extracted with ethyl acetate (3×100 mL). The combined organic extracts were then evaporated to afford crude N-cyclohexyl-2-nitro-4-(1-piperidinylmethyl) aniline as a yellow oil (15.4 g crude yield).

1. temperaturecooled to room temperature
2. stirringAfter stirring for 18 hr at room temperature
3. customthe reaction was quenched by the addition of sodium bicarbonate (sat., aq., 100 mL)
4. extractionthe mixture was extracted with ethyl acetate (3×100 mL)
5. customThe combined organic extracts were then evaporated
6. customto afford

ORD record

ord-188b1e25440344cd90136f99d0007f80

Source dataset

uspto-grants-2006_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07132438B2