Triethylamine → HCID 45082394, compound

HRID 724995

Reaction equation

HRID 724995 reaction equation
[NH2:1][C@@H:2]([C:7]([OH:9])=[O:8])[CH2:3][C:4]([OH:6])=[O:5].[CH2:10](N(CC)CC)[CH3:11]>C(O)C.Cl>[CH3:10][CH2:11][O:8][C:7](=[O:9])[C@@H:2]([CH2:3][C:4]([OH:6])=[O:5])[NH2:1]

Participants

5

Reactant 2

HCID 8471TriethylamineHCID 83887D-Aspartic Acid

Product 1

HCID 45082394HCID 45082394, compoundYield 71%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 702EthanolSolvent2×

Procedure

13.31 g of D-aspartic acid (0.1 mole) are dissolved in 135 ml of absolute ethanol containing 8.7 g of dry hydrogen chloride. The reaction mixture is stirred for about 2 hr. The solution is diluted by addition of 250 ml of absolute ethanol. Triethylamine is then added dropwise until the solution becomes alkaline. After standing for 16 hr at +4° C., the obtained crystals are filtered, washed successively with cold absolute ethanol and ether, then dried. The reaction yields 11.5 g of D-aspartic acid β-ethyl ester (71%).

Workup

  1. waitAfter standing for 16 hr at +4° C.
  2. filtrationthe obtained crystals are filtered
  3. washwashed successively with cold absolute ethanol and ether
  4. customdried

Sources & evidence

ORD record
ord-6624f76bdaf74ef0a4b527870acddc6a
Source dataset
uspto-grants-1998_01
Patent number
US05705522

Linked notes

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