Piperazine → 1-(5-Trifluoromethyl-pyridin-2-yl)-piperazine

HRID 72673

Reaction equation

HRID 72673 reaction equation
[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.Cl[C:8]1[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][N:9]=1>C1COCC1>[F:15][C:14]([F:17])([F:16])[C:11]1[CH:12]=[CH:13][C:8]([N:1]2[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]2)=[N:9][CH:10]=1

Participants

4

Reactant 2

HCID 4837PiperazineHCID 923422-Chloro-5-(trifluoromethyl)pyridine

Product 1

HCID 6676181-(5-Trifluoromethyl-pyridin-2-yl)-piperazine

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Piperazine (1.2 g, 13.77 mM) was heated with 2-chloro-5-(trifluoromethyl)pyridine (0.5 g, 2.75 mmol) in THF (2 mL) for 2 hours. Subsequently the reaction mixture was poured onto crushed ice and extracted with ethyl acetate. The organic layer was washed with sodium bicarbonate and evaporated to furnish the required product.

Workup

  1. additionSubsequently the reaction mixture was poured
  2. customonto crushed ice
  3. extractionextracted with ethyl acetate
  4. washThe organic layer was washed with sodium bicarbonate
  5. customevaporated

Sources & evidence

ORD record
ord-2539442d428d4383a6d9b930dc5daea0
Source dataset
uspto-grants-2014_09
Patent number
US08828999B2

Linked notes

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