Piperazine → 1-(5-Trifluoromethyl-pyridin-2-yl)-piperazine
Reaction equation
[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.Cl[C:8]1[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][N:9]=1>C1COCC1>[F:15][C:14]([F:17])([F:16])[C:11]1[CH:12]=[CH:13][C:8]([N:1]2[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]2)=[N:9][CH:10]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Piperazine (1.2 g, 13.77 mM) was heated with 2-chloro-5-(trifluoromethyl)pyridine (0.5 g, 2.75 mmol) in THF (2 mL) for 2 hours. Subsequently the reaction mixture was poured onto crushed ice and extracted with ethyl acetate. The organic layer was washed with sodium bicarbonate and evaporated to furnish the required product.
Workup
- additionSubsequently the reaction mixture was poured
- customonto crushed ice
- extractionextracted with ethyl acetate
- washThe organic layer was washed with sodium bicarbonate
- customevaporated
Sources & evidence
- ORD record
- ord-2539442d428d4383a6d9b930dc5daea0
- Source dataset
- uspto-grants-2014_09
- Patent number
- US08828999B2
Reaction notes
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