Piperazine → 1-(5-Nitropyridin-2-yl)piperazine
Reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][N:3]=1.[NH:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1>O1CCCC1>[N+:8]([C:5]1[CH:6]=[CH:7][C:2]([N:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)=[N:3][CH:4]=1)([O-:10])=[O:9]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
2-Bromo-5-nitropyridine (0.3 g, 1.48 mmol) was treated with piperazine (0.64 g, 7.89 mmol) in tetrahydrofuran (4 ml) and the reaction mixture was stirred for 30 minutes. Subsequently the reaction mixture was poured onto ice-cold water (25 ml) and extracted with ethyl acetate (25 ml). The organic layer was washed with brine and evaporated to furnish the product.
Workup
- additionSubsequently the reaction mixture was poured onto ice-cold water (25 ml)
- extractionextracted with ethyl acetate (25 ml)
- washThe organic layer was washed with brine
- customevaporated
- customto furnish the product
Sources & evidence
- ORD record
- ord-f5dcf78513fb4a359bf8be3f6ed6cc51
- Source dataset
- uspto-grants-2014_09
- Patent number
- US08828999B2
Reaction notes
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