[C:1]([OH:18])(=O)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].Cl.[NH2:20][C@H:21]([C:27]([OH:29])=[O:28])[CH2:22][CH2:23][CH2:24][CH2:25][NH2:26].C(N(CC)CC)C.C(O)(=O)C>CC(C)=O.O>[O:18]=[C:1]([NH:26][CH2:25][CH2:24][CH2:23][CH2:22][C@@H:21]([C:27]([OH:29])=[O:28])[NH2:20])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16]Following the procedure of A. Paquet Can. J. Chem. 54, 733 (1976), 353 mg. (1 mmol) of the succinimidylester of hexadecanoic acid, prepared as in example 2, was suspended in 2 ml acetone and added to a solution of 183 mg (1 mmol) L-lysine hydrochloride and 0.27 ml (ca. 2 mmol) triethylamine in 2 ml water. The reaction mixture was stirred vigorously for at least 4 h, then neutralized with acetic acid and diluted with water. The precipitate was removed by filtration and washed with water, methanol and ether. Repeated crystallizations from acetic acid/water and acetic acid gave 280 mg (73%) colourless crystals, m.p. 240°-245° C. (reported 210°-220° C.)
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