Hydrochloric Acid → 1-(3-Chloropyridin-2-yl)piperazine hydrochloride

HRID 730706

Reaction equation

HRID 730706 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[C:19]([Cl:20])=[CH:18][CH:17]=[CH:16][N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>CO.CCOC(C)=O>[ClH:20].[Cl:20][C:19]1[C:14]([N:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)=[N:15][CH:16]=[CH:17][CH:18]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 11630777Tert-butyl 4-(3-chloropyridin-2-yl)piperazine-1-carboxylate

Product 1

HCID 204550741-(3-Chloropyridin-2-yl)piperazine hydrochloride

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of the ester from step (a) above (2.98 g, 10 mmol) in MeOH (5 mL) was added saturated solution of hydrogen chloride in EtOAc (50 mL) and the mixture was stirred at room temperature for 4 h. The solvent was removed in vacuo, and the residue was washed with EtOAc and dried in the air to provide the title compound as a light-yellow solid. MS (ESI, pos. ion) m/z: 198 (M+1).

Workup

  1. customThe solvent was removed in vacuo
  2. washthe residue was washed with EtOAc
  3. customdried in the air

Sources & evidence

ORD record
ord-2767beb1e38349508ff8e7d7ae456cc1
Source dataset
uspto-grants-2009_09
Patent number
US07582761B2

Linked notes

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