Hydrochloric Acid → 4-Methoxy-4-phenylpiperidine hydrochloride
Reaction equation
C(OC([N:8]1[CH2:13][CH2:12][C:11]([O:20][CH3:21])([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:22]>CCOC(C)=O>[ClH:22].[CH3:21][O:20][C:11]1([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of the ester from step (b) above (8.6g) and saturated solution of hydrogen chloride in EtOAc (100 mL) was stirred at room temperature for 1 h. The solvent was removed in vacuo and the residue was washed with EtOAc, and dried in vacuo to give the title compound as a white solid. MS (ESI, pos. ion) m/z: 192 (M+1).
Workup
- customThe solvent was removed in vacuo
- washthe residue was washed with EtOAc
- customdried in vacuo
Sources & evidence
- ORD record
- ord-97f8c414d8b74709b8981a755edbd2c7
- Source dataset
- uspto-grants-2009_09
- Patent number
- US07582761B2
Reaction notes
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