Hydrochloric Acid → 4-Chlorobutane-1-sulphonyl chloride
Reaction equation
[S:1]([O-:4])([O-])=[O:2].[Na+].[Na+].C(O[CH2:11][CH2:12][CH2:13][CH2:14][Cl:15])(=O)C.[ClH:16]>O>[Cl:15][CH2:14][CH2:13][CH2:12][CH2:11][S:1]([Cl:16])(=[O:4])=[O:2]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
Add anhydrous sodium sulfite (16.8 g, 130 mmol) to a solution of 4-chlorobutyl acetate (20.0 g, 133 mmol) in water (50 mL) and reflux the mixture for 20 h. Cool to room temperature and add concentrated HCl (19.0 mL) and reflux for 1 h. Cool the mixture to room temperature, neutralize to about pH=7. Concentrate to about one half the volume, filter away the sodium chloride. Concentrate and dry to give the title compound.
Workup
- temperaturereflux the mixture for 20 h
- temperaturereflux for 1 h
- temperatureCool the mixture to room temperature
- concentrationConcentrate to about one half the volume
- filtrationfilter away the sodium chloride
- concentrationConcentrate
- customdry
Sources & evidence
- ORD record
- ord-d56b9ba0d8e84946ae969baed6e81415
- Source dataset
- uspto-grants-2009_09
- Patent number
- US07585885B2
Reaction notes
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