Pamidronic Acid → Alendronic Acid
Reaction equation
[CH2:1]([C:4]([P:10]([OH:13])([OH:12])=[O:11])([P:6]([OH:9])([OH:8])=[O:7])[OH:5])[CH2:2]N.C[CH2:15][N:16](CC)CC>O>[CH2:2]([CH2:15][NH2:16])[CH2:1][C:4]([P:10]([OH:13])([OH:12])=[O:11])([P:6]([OH:9])([OH:8])=[O:7])[OH:5]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
The NHS ester (0.35 g, 0.62 mmol) was dissolved in H2O (30 mL), and pamidronate (0.52 g, 2.23 mmol) and Et3N (1.7 mL, 12.4 mmol) were added. The reaction solution was stirred for 24 h at room temperature. Subsequently, the H2O was removed in the vacuum. The product obtained was purified by means of HPLC.
Workup
- customSubsequently, the H2O was removed in the vacuum
- customThe product obtained
- customwas purified by means of HPLC
Sources & evidence
- ORD record
- ord-63709912d71b4b3b8f382421cafd90e3
- Source dataset
- uspto-grants-2014_09
- Patent number
- US08829233B2
Reaction notes
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