Hydrochloric Acid → HCID 57497648, compound

Reaction equation

[CH3:1][N:2]([CH2:4][CH:5]([OH:25])[CH2:6][O:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[CH3:3].[ClH:26]>C(OCC)(=O)C.O1CCOCC1>[ClH:26].[CH3:1][N:2]([CH2:4][CH:5]([OH:25])[CH2:6][O:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1)[CH3:3]

Participants

Procedure

0.225 g of 3-(N,N-dimethylamino)-1-[2-(5-phenylpentyl)phenoxy]-2-propanol [prepared as described in step (b) above] was dissolved in a small amount of ethyl acetate, and 0.25 ml of a 4N solution of hydrogen chloride in dioxane was added to the solution. The mixture was then concentrated by distillation under reduced pressure. Pentane was added to the resulting concentrate, and the mixture was shaken and then the upper pentane layer was removed. The operation was repeated twice and the resulting oil was dried in vacuo, to give 0.235 g (yield 94%) of the title compound as a colorless oil.