Hydrochloric Acid → (1,2,3,4-Tetrahydroisoquinolin-4-yl)methanol
Reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([CH2:11][OH:12])=[CH:3][N:2]=1.Cl>CO.[Pt](=O)=O>[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]([CH2:11][OH:12])[CH2:3][NH:2]1Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
0.50 mg (3.1 mmol) isoquinolin-4-yl-methanol, 75 mg platinum dioxide and 3.2 mL 1N hydrochloric acid solution were hydrogenated in 50 mL methanol for 4 h at RT under a hydrogen atmosphere at 50 psi. The reaction mixture was filtered and the filtrate was concentrated to dryness by rotary evaporation.
Workup
- filtrationThe reaction mixture was filtered
- concentrationthe filtrate was concentrated to dryness by rotary evaporation
Sources & evidence
- ORD record
- ord-83d6649fa9da4783a01162a16a2d33a1
- Source dataset
- uspto-grants-2014_09
- Patent number
- US08829006B2
Reaction notes
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