Hydrochloric Acid → 4-Methyl-1,2,3,4-tetrahydroisoquinoline hydrochloride
Reaction equation
[H][H].[CH3:3][C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=[N:6][CH:5]=1.[ClH:14]>CO.[Pt](=O)=O>[ClH:14].[CH3:3][CH:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:7][NH:6][CH2:5]1Participants
6
Procedure
In a hydrogen atmosphere 0.50 g (3.5 mmol) 4-methyl-isoquinoline, 50 mg platinum dioxide in 50 mL methanol and 3.5 mL 1M aqueous hydrochloric acid solution were hydrogenated at RT and 3 bar for 4 h. After removal of the catalyst by suction filtering the reaction mixture was evaporated down. A mixture of educt and product was obtained, which was reacted further without any further purification.
Workup
- customwere hydrogenated at RT
- customAfter removal of the catalyst by suction
- filtrationfiltering the reaction mixture
- customwas evaporated down
- additionA mixture of educt
- customproduct was obtained
- customwhich was reacted further without any further purification
Sources & evidence
- ORD record
- ord-1321a3bcf39b40b99dddf7a6e3b25de7
- Source dataset
- uspto-grants-2014_09
- Patent number
- US08829006B2
Reaction notes
Loading…