Hydrochloric Acid → Benzoic acid, 2-(aminosulfonyl)-, methyl ester

Reaction equation

Cl.[S:2]1([C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:6](=[O:7])[NH:5]1)(=[O:4])=[O:3].[CH3:14][OH:15]>>[CH3:14][O:15][C:6](=[O:7])[C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][C:13]=1[S:2](=[O:4])(=[O:3])[NH2:5]

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 887Methanol

HCID 5143Saccharin

Product 1

HCID 42546Benzoic acid, 2-(aminosulfonyl)-, methyl ester

Procedure

An HCl stream is led under cooling into a suspension of 143.3 g (0.78 mol) in 600 ml absolute methanol until saturation. Subsequently the solution is refluxed yet two hours until the saccharine has gone completely into solution and the reaction has terminated.

Workup

customthe reaction has terminated

Sources & evidence

ORD record: ord-7682b66929384626b8eedbdba4fb52da
Source dataset: uspto-grants-1986_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04601746

Reaction notes

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