Diisopropylethylamine → HCID 58386482, compound

HRID 74614

Reaction equation

HRID 74614 reaction equation
Cl.Cl.[NH:3]1[CH2:8][CH2:7][CH:6]([N:9]2[C:17]3[C:12](=[N:13][CH:14]=[CH:15][CH:16]=3)[NH:11][C:10]2=[O:18])[CH2:5][CH2:4]1.[Br:19][C:20]1[N:25]=[C:24](Br)[CH:23]=[CH:22][N:21]=1.CCN(C(C)C)C(C)C>CN(C1C=CN=CC=1)C.C(O)C>[Br:19][C:20]1[N:25]=[C:24]([N:3]2[CH2:4][CH2:5][CH:6]([N:9]3[C:17]4[C:12](=[N:13][CH:14]=[CH:15][CH:16]=4)[NH:11][C:10]3=[O:18])[CH2:7][CH2:8]2)[CH:23]=[CH:22][N:21]=1

Participants

6

Reactant 3

HCID 81531DiisopropylethylamineHCID 149763012,4-DibromopyrimidineHCID 222931811-(piperidin-4-yl)-1H,2H,3H-imidazo[4,5-b]pyridin-2-one dihydrochloride

Product 1

HCID 58386482HCID 58386482, compound

Reagents, catalysts & solvents 2

HCID 142844-(Dimethylamino)pyridineCatalystHCID 702EthanolSolvent

Procedure

1.4 g (4.8 mmol) 1-piperidin-4-yl-1,3-dihydro-imidazo[4,5-b]pyridin-2-one-dihydrochloride, 1.1 g (4.8 mmol) 2,4-dibromo-pyrimidine, a spatula tip of DMAP and 3.3 mL (19.1 mmol) DIPEA in 35 mL ethanol were stirred at RT. After the reaction had ended the precipitate was suction filtered, washed with a little ethanol and dried.

Workup

  1. filtrationfiltered
  2. washwashed with a little ethanol
  3. customdried

Sources & evidence

ORD record
ord-0fbf7c5cb04343679509e7c8f4af0f70
Source dataset
uspto-grants-2014_09
Patent number
US08829006B2

Linked notes

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