Bms-973013 → HCID 58386605, compound

HRID 74665

Reaction equation

HRID 74665 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([N:7]2[C:15]3[C:10](=[N:11][CH:12]=[CH:13][CH:14]=3)[NH:9][C:8]2=[O:16])[CH2:3][CH2:2]1.Cl[C:18]1[CH:23]=[C:22]([C:24]([N:26]2[C:34]3[C:29](=[CH:30][C:31]([F:36])=[C:32]([F:35])[CH:33]=3)[CH2:28][CH2:27]2)=[O:25])[CH:21]=[CH:20][N:19]=1>CN1C(=O)CCC1>[F:36][C:31]1[CH:30]=[C:29]2[C:34](=[CH:33][C:32]=1[F:35])[N:26]([C:24]([C:22]1[CH:21]=[CH:20][N:19]=[C:18]([N:1]3[CH2:2][CH2:3][CH:4]([N:7]4[C:15]5[C:10](=[N:11][CH:12]=[CH:13][CH:14]=5)[NH:9][C:8]4=[O:16])[CH2:5][CH2:6]3)[CH:23]=1)=[O:25])[CH2:27][CH2:28]2

Participants

4

Reactant 2

HCID 22293182Bms-973013HCID 58386704HCID 58386704, compound

Product 1

HCID 58386605HCID 58386605, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

1.0 g (4.6 mmol) 1-piperidin-4-yl-1,3-dihydroimidazo[4,5-b]pyridin-2-one, 0.45 g (1.5 mmol) (2-chloro-pyridin-4-yl)-(5,6-difluoro-2,3-dihydro-indol-1-yl)-methanone were stirred in 4 mL of NMP for 4 h at 130° C. The reaction mixture was purified by HPLC. The product-containing fractions were combined and freeze-dried.

Workup

  1. customThe reaction mixture was purified by HPLC
  2. customfreeze-dried

Sources & evidence

ORD record
ord-032d9bc1f83c41c89fa34d6aa31f8612
Source dataset
uspto-grants-2014_09
Patent number
US08829006B2

Linked notes

Loading…