Bromobenzene → HCID 59357764, compound

Temperature

100 °C

2,4-diphenyl-6-fluoroaniline (12 mmol), bromobenzene (10 mmol), tris(dibenzylideneacetone)dipalladium(0) (0.15 mmol), (±)-2,2′-bis(diphenylphosphine)-1,1′-binaphthalene (0.3 mmol) and sodium tert-butoxie (14 mmol) are put in a two-neck round-bottom flask and dissolved in toluene (30 mL). Subsequently, the resulting solution is stirred in a bath under a temperature of about 100° C. for 24 hours. After completion of the reaction, toluene is removed. The reaction mixture is extracted with dichloromethane and water, and then being distilled under reduced pressure. The resulting residence is filtered by silica gel column and distilled under reduced pressure again. Next, by re-crystallizing and filtering with dichloromethane and petroleum ether, 2,4-diphenyl-6-fluoro-N-phenylbenzenamine (2.5 g) is yielded.

1. customis removed
2. extractionThe reaction mixture is extracted with dichloromethane and water
3. distillationbeing distilled under reduced pressure
4. filtrationThe resulting residence is filtered by silica gel column
5. distillationdistilled under reduced pressure again
6. customNext, by re-crystallizing
7. filtrationfiltering with dichloromethane and petroleum ether

ORD record

ord-d5ac651d62894259b91c0489bef21596

Source dataset

uspto-grants-2014_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08835020B2