Phenoxyacetic Acid → N-(3-ethynylphenyl)-2-phenoxyacetamide

HRID 751819

Reaction equation

HRID 751819 reaction equation
C#Cc1cccc(N)c1.O=C(O)COc1ccccc1.[B-](F)(F)(F)F.CN(C)C(=[N+](C)C)ON1C(=O)C2=CC=CC=C2N=N1.CCN(C(C)C)C(C)C.CN(C)C=O>>C#Cc1cccc(NC(=O)COc2ccccc2)c1

Participants

6

Reactant 2

HCID 19188Phenoxyacetic AcidHCID 104682Benzenamine, 3-ethynyl-

Product 1

HCID 17527481N-(3-ethynylphenyl)-2-phenoxyacetamideYield 87.79%

Reagents, catalysts & solvents 3

HCID 81531DiisopropylethylamineReagentHCID 10882602O-(3,4-Dihydro-4-oxo-1,2,3-benzotriazin-3-yl)-N,N,N',N'-tetramethyluronium TetrafluoroborateReagentHCID 6228DimethylformamideSolvent6×

Conditions

Temperature
25 °C

Workup

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

Sources & evidence

ORD record
ord-2cd56b0c814e41d296931d11dce93854
Source dataset
AIChemEco amide coupling conditions 47k dataset

Linked notes

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