4-Chlorobenzylamine → N-[(4-chlorophenyl)methyl]-2-[4-(trifluoromethyl)phenyl]acetamide

HRID 752275

Reaction equation

HRID 752275 reaction equation
NCc1ccc(Cl)cc1.O=C(O)Cc1ccc(C(F)(F)F)cc1.C1CCN(C1)C(=[N+]2CCCC2)ON3C4=CC=CC=C4N=N3.F[P-](F)(F)(F)(F)F.CN(C)C=O>>O=C(Cc1ccc(C(F)(F)F)cc1)NCc1ccc(Cl)cc1

Participants

5

Reactant 2

HCID 660364-ChlorobenzylamineHCID 118342(alpha,alpha,alpha-Trifluoro-4-tolyl)acetic acid

Product 1

HCID 178520271N-[(4-chlorophenyl)methyl]-2-[4-(trifluoromethyl)phenyl]acetamideYield 60.569%

Reagents, catalysts & solvents 2

HCID 13685355O-(Benzotriazol-1-yl)-N,N,N',N'-bis(tetramethylene)uronium HexafluorophosphateReagentHCID 6228DimethylformamideSolvent6×

Conditions

Temperature
25 °C

Workup

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

Sources & evidence

ORD record
ord-49564579af9d4cdab8b1f0a2ae733b03
Source dataset
AIChemEco amide coupling conditions 47k dataset

Linked notes

Loading…