3,5-Dimethylbenzoic acid → N-methoxy-N,3,5-trimethylbenzamide
Reaction equation
CNOC.Cc1cc(C)cc(C(=O)O)c1.COC1=NC(=NC(=N1)Cl)Cl.CN1CCOCC1.CN(C)C=O>>CON(C)C(=O)c1cc(C)cc(C)c1Participants
6
Reactant 2
Product 1
Reagents, catalysts & solvents 3
Conditions
- Temperature
- 25 °C
Workup
- addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
- addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
- aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
- addition380 uL MeCN solvent were added to the transfer plate
- aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
- addition180 uL MeCN added to filter plate 1 for LCMS analysis
- aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
- addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
- customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM
Sources & evidence
- ORD record
- ord-a99e0d9ccace4c5095bf5217c914c0e3
- Source dataset
- AIChemEco amide coupling conditions 47k dataset
Reaction notes
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