N-Methyl-4-anisidine → HCID 178492276, compound
Reaction equation
CNc1ccc(OC)cc1.O=C(O)c1ncccn1.CCOC(=O)C(=NO[P+](N1CCCC1)(N2CCCC2)N3CCCC3)C#N.F[P-](F)(F)(F)(F)F.CCN(C(C)C)C(C)C.CN(C)C=O>>COc1ccc(N(C)C(=O)c2ncccn2)cc1Participants
6
Reactant 2
Product 1
Reagents, catalysts & solvents 3
HCID 81531DiisopropylethylamineReagent
HCID 75251209Pyoxime; (T-4)-[ethyl cyano(hydroxyimino)acetato-O2]tri-1-pyrrolidinyl-Phosphorus(1+) hexafluorophosphate(1-); (T-4)-[ethyl 2-cyano-2-[(hydroxy-kO)imino]acetato]tri-1-pyrrolidinyl-Phosphorus(1+) hexafluorophosphate(1-)Reagent
HCID 6228DimethylformamideSolvent6×Conditions
- Temperature
- 25 °C
Workup
- addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
- addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
- aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
- addition380 uL MeCN solvent were added to the transfer plate
- aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
- addition180 uL MeCN added to filter plate 1 for LCMS analysis
- aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
- addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
- customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM
Sources & evidence
- ORD record
- ord-1bb9b5b544a34c24a210db505a760c21
- Source dataset
- AIChemEco amide coupling conditions 47k dataset
Reaction notes
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