[F:1][C:2]1[CH:20]=[CH:19][C:5]2[N:6]=[C:7]([NH:9][C:10]([CH:12]3[C:14]([CH3:16])([CH3:15])[C:13]3([CH3:18])[CH3:17])=[O:11])[S:8][C:4]=2[CH:3]=1.[H-].[Na+].[CH3:23][O:24][CH2:25][CH2:26]Br>CN(C=O)C.C1COCC1>[F:1][C:2]1[CH:20]=[CH:19][C:5]2[N:6]([CH2:26][CH2:25][O:24][CH3:23])[C:7](=[N:9][C:10]([CH:12]3[C:13]([CH3:18])([CH3:17])[C:14]3([CH3:16])[CH3:15])=[O:11])[S:8][C:4]=2[CH:3]=1To a solution of the product of Example 112A (1 equiv) in 1:1 DMF/THF (0.1 M) was added sodium hydride (60% dispersion in mineral oil, 1.2 equiv) and 2-bromoethyl methyl ether (1.2 equiv).
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