Hydrochloric Acid → 3-Amino-6-bromopyrazine-2-carboxylic acid
Reaction equation
[NH2:1][C:2]1[C:3]([C:9]([O:11]C)=[O:10])=[N:4][C:5]([Br:8])=[CH:6][N:7]=1.[OH-].[Li+].Cl>CO.O>[NH2:1][C:2]1[C:3]([C:9]([OH:11])=[O:10])=[N:4][C:5]([Br:8])=[CH:6][N:7]=1Participants
6
Conditions
- Temperature
- 90 °C
Procedure
A mixture of methyl 3-amino-6-bromo-pyrazine-2-carboxylate (5.11 g, 22.02 mmol) and lithium hydroxide (2.637 g, 110.1 mmol) in MeOH (20 mL) and H2O (20 mL) was heated to 90° C. for 2 hours. The reaction mixture was allowed to cool and neutralised with HCl and the resultant precipitate collected by filtration. Taken on to the next step without further purification (4.80 g, 99% Yield).
Workup
- temperatureto cool
- filtrationthe resultant precipitate collected by filtration
- customTaken on to the next step without further purification (4.80 g, 99% Yield)
Sources & evidence
- ORD record
- ord-b77f463d521b4c8f9bd4a22919f5bc73
- Source dataset
- uspto-grants-2014_09
- Patent number
- US08841308B2
Reaction notes
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