N-methyl-2-pyrrolidone → 5-Amino-2-fluoro-4-methylbenzonitrile

Reaction equation

[Br:1][c:2]1[c:3]([F:10])[cH:4][c:5]([CH3:9])[c:6]([NH2:7])[cH:8]1.[CH3:14][N:15]1[CH2:16][CH2:17][CH2:18][C:19]1=[O:20].[Cu:11][C:12]#[N:13].[Cu:21][I:22]>>[c:2]1([C:12]#[N:13])[c:3]([F:10])[cH:4][c:5]([CH3:9])[c:6]([NH2:7])[cH:8]1

Participants

Reactant 4

HCID 13387N-methyl-2-pyrrolidone

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)

HCID 27827865-Bromo-4-fluoro-2-methylaniline

HCID 178418546HCID 178418546, compound

Product 1

HCID 866774495-Amino-2-fluoro-4-methylbenzonitrile

Sources & evidence

ORD record: ord-6577eabf927743839cb128ecb448ea0d
Source dataset: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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