Acetone → 4-(4-Chloro-5-iodo-pyrrolo[2,3-d]pyrimidin-7-yl)-cyclohexanone

HRID 819105Notes

Reaction equation

HRID 819105 reaction equation
[CH3:28][C:29](=[O:30])[CH3:31].[Cl:1][c:2]1[c:3]2[c:4]([n:5][cH:6][n:7]1)[n:8]([CH:12]1[CH2:13][CH2:14][C:15]3([O:16][CH2:19][CH2:18][O:17]3)[CH2:20][CH2:21]1)[cH:9][c:10]2[I:11].[ClH:22].[O:23]1[CH2:24][CH2:25][CH2:26][CH2:27]1>>[Cl:1][c:2]1[c:3]2[c:4]([n:5][cH:6][n:7]1)[n:8]([CH:12]1[CH2:13][CH2:14][C:15](=[O:16])[CH2:20][CH2:21]1)[cH:9][c:10]2[I:11]

Participants

5

Reactant 4

HCID 180AcetoneHCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 227363864-chloro-5-iodo-7-(1,4-dioxaspiro[4.5]decan-8-yl)-7H-pyrrolo[2,3-d]pyrimidine

Product 1

HCID 227364134-(4-Chloro-5-iodo-pyrrolo[2,3-d]pyrimidin-7-yl)-cyclohexanone

Sources & evidence

ORD record
ord-56cb9f199ca24996821f2f09b3edab7a
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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