Chloride → 6-fluoro-2-[2-(2-methyl-thiazol-4-yl)-vinyl]-3-(2-methyl-phenyl)-3H-quinazolin-4-one

HRID 822455

Reaction equation

HRID 822455 reaction equation
[CH3:21][C:22]([O:23][C:24](=[O:25])[CH3:26])=[O:27].[CH3:28][c:29]1[s:30][cH:31][c:32]([CH:34]=[O:35])[n:33]1.[Cl-:37].[Cl-:39].[F:1][c:2]1[cH:3][c:4]2[c:5](=[O:20])[n:6](-[c:13]3[c:14]([CH3:19])[cH:15][cH:16][cH:17][cH:18]3)[c:7]([CH3:12])[n:8][c:9]2[cH:10][cH:11]1.[OH2:36].[Zn+2:38]>>[F:1][c:2]1[cH:3][c:4]2[c:5](=[O:20])[n:6](-[c:13]3[c:14]([CH3:19])[cH:15][cH:16][cH:17][cH:18]3)[c:7]([CH:12]=[CH:34][c:32]3[cH:31][s:30][c:29]([CH3:28])[n:33]3)[n:8][c:9]2[cH:10][cH:11]1

Participants

7

Reactant 6

HCID 312Chloride2×HCID 962WaterHCID 7918Acetic AnhydrideHCID 32051Zinc(2+)HCID 634674(3H)-Quinazolinone, 6-fluoro-2-methyl-3-(2-methylphenyl)-HCID 27631912-Methyl-1,3-thiazole-4-carbaldehyde

Product 1

HCID 544906406-fluoro-2-[2-(2-methyl-thiazol-4-yl)-vinyl]-3-(2-methyl-phenyl)-3H-quinazolin-4-one

Sources & evidence

ORD record
ord-05ecbf2a5ae446b3b2847cdb4dd46c4d
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Linked notes

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