Dimethylamine → HCID 51000867, compound

To a solution of 5-({3-[(3R,4S)-3-Hydroxytetrahydro-2H-pyran-4-yl]-4-oxo-3,4-dihydrobenzo[h]quinazolin-6-yl}methyl)pyridine-2-carboxylic acid (Example 18, 0.030 g, 0.070 mmol) in 1 mL of DMF was added dimethylamine (0.087 mL, 0.17 mmol), triethylamine (0.019 mL, 0.14 mmol), and benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate (0.046 g, 0.10 mmol). After 1 h, additional dimethylamine (0.17 mL, 0.35 mmol) was added. After 2 h, the mixture was diluted with water and dichloromethane, and the organic solution was dried over sodium sulfate, filtered, and concentrated in vacuo. The residue was purified via silica gel chromatography, eluting with 0-5% methanol in dichloromethane to provide the title compound that gave proton NMR spectra consistent with theory and a mass ion (ES+) of 459.2039 for [M+H]+ [Calc'd for C26H27N4O4, [M+H]+=459.2027]: 1H NMR (400 MHz, CDCl3) δ 8.89-8.87 (m, 1H), 8.41 (s, 1H), 8.28 (s, 1H), 7.76 (s, 1H), 7.70 (d, J=8.4 Hz, 1H), 7.63-7.54 (m, 2H), 7.41 (s, 2H), 4.82-4.75 (m, 1H), 4.34 (br s, 1H), 4.27 (s, 2H), 4.23-4.18 (m, 2H), 4.03 (s, 1H), 3.58-3.51 (m, 1H), 3.34-3.28 (m, 1H), 3.09 (s, 3H), 2.99 (s, 3H), 2.23-2.12 (m, 1H), 2.00-1.91 (m, 1H).

1. waitAfter 2 h
2. dry with materialthe organic solution was dried over sodium sulfate
3. filtrationfiltered
4. concentrationconcentrated in vacuo
5. customThe residue was purified via silica gel chromatography
6. washeluting with 0-5% methanol in dichloromethane

ORD record

ord-bc8fa2d33ce64173a904ff9a4cae33e3

Source dataset

uspto-grants-2014_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08846702B2