Hydrochloric Acid → 7',8'-dimethyl-2',3'-dihydro-1'H-spiro[cyclobutane-1,4'-quinolin]-6'-ol

Reaction equation

[CH2:19]1[O:20][CH2:21][CH2:22][CH2:23]1.[ClH:18].[OH:1][c:2]1[cH:3][c:4]2[c:5]([c:6]([CH3:9])[c:7]1[CH3:8])[NH:10][C:11](=[O:17])[CH2:12][C:13]21[CH2:14][CH2:15][CH2:16]1>>[OH:1][c:2]1[cH:3][c:4]2[c:5]([c:6]([CH3:9])[c:7]1[CH3:8])[NH:10][CH2:11][CH2:12][C:13]21[CH2:14][CH2:15][CH2:16]1

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 8028Tetrahydrofuran

HCID 690541776'-hydroxy-7',8'-dimethyl-1'H-spiro[cyclobutane-1,4'-quinolin]-2'(3'H)-one

Product 1

HCID 578035137',8'-dimethyl-2',3'-dihydro-1'H-spiro[cyclobutane-1,4'-quinolin]-6'-ol

Sources & evidence

ORD record: ord-1b5ba2d884e8406fb901b4577b9fea12
Source dataset: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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