Tetrahydrofuran → 3'-Chloro-2',6'-difluoroacetophenone
Reaction equation
[Al+3:27].[Cl:13][c:14]1[c:15]([Cl:16])[cH:17][cH:18][c:19]([F:20])[c:21]1[C:22](=[O:23])[CH3:24].[Cl:1][c:2]1[c:3]([F:12])[c:4]([CH:9]([CH3:10])[OH:11])[c:5]([F:8])[cH:6][cH:7]1.[H-:25].[H-:28].[H-:29].[H-:30].[Li+:26].[O:31]1[CH2:32][CH2:33][CH2:34][CH2:35]1>>[Cl:1][c:2]1[c:3]([F:12])[c:4]([C:9]([CH3:10])=[O:11])[c:5]([F:8])[cH:6][cH:7]1Participants
7
Sources & evidence
- ORD record
- ord-90619a6793a940aa9619363410976849
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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