Tetrahydrofuran → N-[(2-amino-1,3-thiazol-4-yl)methyl]-6-chloro-5-fluoro-2-methyl-4-pyrimidinamine

Reaction equation

[CH2:27]1[O:28][CH2:29][CH2:30][CH2:31]1.[CH3:11][NH:12][CH2:13][c:14]1[n:15][c:16]([NH2:19])[s:17][cH:18]1.[CH3:20][CH2:21][N:22]([CH2:23][CH3:24])[CH2:25][CH3:26].[Cl:1][c:2]1[n:3][c:4]([CH3:10])[n:5][c:6]([Cl:9])[c:7]1[F:8]>>[c:2]1([NH:12][CH2:13][c:14]2[n:15][c:16]([NH2:19])[s:17][cH:18]2)[n:3][c:4]([CH3:10])[n:5][c:6]([Cl:9])[c:7]1[F:8]