Acetate → Methyl 2-Acetamido-3-[2-(2-(t-butoxycarbonylamino)ethoxy)-4-cyanophenyl]acrylate

HRID 836128

Reaction equation

HRID 836128 reaction equation
[C:1](#[N:2])[c:3]1[cH:4][cH:5][c:6]([I:20])[c:7]([O:8][CH2:9][CH2:10][NH:11][C:12]([O:13][C:14]([CH3:15])([CH3:16])[CH3:17])=[O:18])[cH:19]1.[C:21]([CH3:22])(=[O:23])[NH:24][C:25]([C:26](=[O:27])[O:28][CH3:29])=[CH2:30].[CH3:31][CH2:32][N:33]([CH2:34][CH3:35])[CH2:36][CH3:37].[CH3:38][c:39]1[cH:40][cH:41][cH:42][cH:43][c:44]1[P:45]([c:46]1[cH:47][cH:48][cH:49][cH:50][c:51]1[CH3:52])[c:53]1[cH:54][cH:55][cH:56][cH:57][c:58]1[CH3:59].[CH3:60][C:61]#[N:62].[O-:64][C:65]([CH3:66])=[O:67].[O-:68][C:69]([CH3:70])=[O:71].[Pd+2:63]>>[C:1](#[N:2])[c:3]1[cH:4][cH:5][c:6]([CH:30]=[C:25]([NH:24][C:21]([CH3:22])=[O:23])[C:26](=[O:27])[O:28][CH3:29])[c:7]([O:8][CH2:9][CH2:10][NH:11][C:12]([O:13][C:14]([CH3:15])([CH3:16])[CH3:17])=[O:18])[cH:19]1

Participants

8

Reactant 7

HCID 175Acetate2×HCID 6342AcetonitrileHCID 8471TriethylamineHCID 80271Tri-o-tolylphosphineHCID 98644Methyl 2-acetamidoacrylateHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 11111864t-Butyl [2-(5-cyano-2-iodophenoxy)ethyl]carbamate

Product 1

HCID 68833044Methyl 2-Acetamido-3-[2-(2-(t-butoxycarbonylamino)ethoxy)-4-cyanophenyl]acrylate

Sources & evidence

ORD record
ord-0bd63c37799f47cab7faff58840abab8
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Linked notes

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