2-Methoxyethylamine → 2-(4-Bromo-1H-pyrazol-1-yl)-N-(2-methoxyethyl)ethanamine
Reaction equation
[CH3:1][O:2][CH2:3][CH2:4][NH2:5].[Br:6][C:7]1[CH:8]=[N:9][N:10]([CH2:12][CH2:13]Cl)[CH:11]=1>CS(C)=O.CCOC(C)=O>[Br:6][C:7]1[CH:8]=[N:9][N:10]([CH2:12][CH2:13][NH:5][CH2:4][CH2:3][O:2][CH3:1])[CH:11]=1Participants
5
Procedure
A solution of 2-methoxyethanamine (8.9 mL, 102.06 mmol) and chloride 75 (7.13 g, 34.02 mmol) in DMSO (20 mL) was heated at 60° C. 5 h. The mixture was then cooled to room temperature, diluted with EtOAc, washed with aqueous sodium bicarbonate, water and brine.
Workup
- custom5 h
- washwashed with aqueous sodium bicarbonate, water and brine
Sources & evidence
- ORD record
- ord-d2b70bd9f5b946e39495ccc7c33c597b
- Source dataset
- uspto-grants-2014_09
- Patent number
- US08846927B2
Reaction notes
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