1,2-Dichloroethane → HCID 19882549, compound
Reaction equation
[OH:1][C:2]1[C:11]([OH:12])=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][CH2:6][C:7]2=[O:13].Cl[CH2:15][CH2:16]Cl.C([O-])([O-])=O.[K+].[K+]>CS(C)=O>[CH2:15]1[CH2:16][O:12][C:11]2[C:2](=[C:3]3[C:8](=[CH:9][CH:10]=2)[C:7](=[O:13])[CH2:6][CH2:5][CH2:4]3)[O:1]1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
5,6-Dihydroxy-1-tetralone (6 g) was heated at 125° C. with 1,2-dichloroethane (7 ml) and K2CO3 (14 g) in DMSO (70 ml) under N2 for 45 min. The reaction was quenched with ice water then extracted with Et2O. The aqueous layer was removed, then EtOAc added to the remaining organics. This solution was dried (MgSO4), filtered and evaporated to give the desired product.
Workup
- customThe reaction was quenched with ice water
- extractionthen extracted with Et2O
- customThe aqueous layer was removed
- additionEtOAc added to the remaining organics
- dry with materialThis solution was dried (MgSO4)
- filtrationfiltered
- customevaporated
Sources & evidence
- ORD record
- ord-4828b4d186554648ac9f5712d539e94e
- Source dataset
- uspto-grants-1992_08
- Patent number
- US05140040
Reaction notes
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