Oxalyl chloride → 2,6-Di(propan-2-yl)benzoyl chloride
Reaction equation
[CH:1]([C:4]1[CH:12]=[CH:11][CH:10]=[C:9]([CH:13]([CH3:15])[CH3:14])[C:5]=1[C:6](O)=[O:7])([CH3:3])[CH3:2].C(Cl)(=O)C([Cl:19])=O>CN(C)C=O>[CH:1]([C:4]1[CH:12]=[CH:11][CH:10]=[C:9]([CH:13]([CH3:15])[CH3:14])[C:5]=1[C:6]([Cl:19])=[O:7])([CH3:3])[CH3:2]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of 2,6-diisopropylbenzoic acid (12.8 g, 0.062 mol), oxalyl chloride (25 mL), and dimethylformamide (2 drops) was stirred overnight at room temperature. The volatiles were removed on the rotary evaporator and the residue dried to yield an orange oil, 12.65 g, 90.9%.
Workup
- customThe volatiles were removed on the rotary evaporator
- customthe residue dried
- customto yield an orange oil, 12.65 g, 90.9%
Sources & evidence
- ORD record
- ord-44d2c2261a20479093ddf08237117330
- Source dataset
- uspto-grants-2000_01
- Patent number
- US06017905
Reaction notes
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