1,3-Dibromopropane → 1-(3-Bromopropyl)piperidine
Reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[Br:7][CH2:8][CH2:9][CH2:10]Br.C(=O)([O-])[O-].[Na+].[Na+]>O>[Br:7][CH2:8][CH2:9][CH2:10][N:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
Combine piperidine (5.0 g, 58.7 mmol), fused sodium acetate (4.82 g, 58.7 mmol) and 1,3-dibromopropane (11.85 g, 58.7 mmol) and reflux for several hours. Pour the mixture into water and add sodium carbonate to create a basic pH. Remove the unreacted 1,3-dibromopropane by distillation. Extract the left-over residue with ether and evaporate to obtain the final, desired compound.
Workup
- customRemove the unreacted 1,3-dibromopropane
- distillationby distillation
- extractionExtract the left-over residue with ether
- customevaporate
Sources & evidence
- ORD record
- ord-2b13a16a6c9d4d78856a320ca8b39478
- Source dataset
- uspto-grants-2007_08
- Patent number
- US07253165B2
Reaction notes
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